Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging
Identifieur interne : 000A07 ( Main/Exploration ); précédent : 000A06; suivant : 000A08Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging
Auteurs : Pierre Y. Marie [France] ; Nicolas Danchin [France] ; Fabrice Branly [France] ; Michaël Angio [France] ; Alain Grentzinger [France] ; Jean M. Virion [France] ; Benoit Brouant [France] ; Pierre Olivier [France] ; Gilles Karcher [France] ; Yves Juillière [France] ; Fa Ez Zannad [France] ; Alain Bertrand [France]Source :
- Journal of the American College of Cardiology [ 0735-1097 ] ; 1999.
English descriptors
Abstract
OBJECTIVES The purpose of this study was to determine whether antianginal medications modify the prognostic significance of exercise single photon emission computed tomography (SPECT) ischemia. BACKGROUND Antianginal medications (especially beta-adrenergic blocking agents) limit exercise SPECT ischemia, but it is not known whether such medications also modify the prognostic effect of exercise SPECT ischemia. METHODS We included 352 patients with coronary heart disease, who had exercise Tl-201 SPECT and coronary angiography, and who were initially treated medically. Survival Cox models were applied in patients for whom classes of antianginal medications taken at exercise SPECT were the same as those prescribed for follow-up (GI; n = 136), and in patients for whom new classes of antianginal medications, including beta-blockers (GII; n = 79) or not including beta-blockers (GIII; n = 113), were added for follow-up. RESULTS During a mean 5.3 ± 1.6 years of follow-up, 45 patients had cardiac death or myocardial infarction. Variables reflecting necrosis (irreversible defect extent, left ventricular ejection fraction) and those from coronary angiography provided equivalent prognostic information in the three groups. In contrast, the SPECT variable reflecting ischemia (reversible defect extent), which provided comparable prognostic information in GI (p = 0.005) and GIII (p = 0.004), lost its prognostic significance (p = 0.54) in GII, and was associated with a lower relative risk in GII than in GI or GIII (both p < 0.05). CONCLUSIONS In patients with coronary heart disease, the introduction of antianginal medications, when including beta-blockers, appears to have a favorable effect on the deleterious prognostic effect of exercise ischemia.
Url:
DOI: 10.1016/S0735-1097(99)00156-4
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging</title><author><name sortKey="Marie, Pierre Y" sort="Marie, Pierre Y" uniqKey="Marie P" first="Pierre Y" last="Marie">Pierre Y. Marie</name></author><author><name sortKey="Danchin, Nicolas" sort="Danchin, Nicolas" uniqKey="Danchin N" first="Nicolas" last="Danchin">Nicolas Danchin</name></author><author><name sortKey="Branly, Fabrice" sort="Branly, Fabrice" uniqKey="Branly F" first="Fabrice" last="Branly">Fabrice Branly</name></author><author><name sortKey="Angio, Michael" sort="Angio, Michael" uniqKey="Angio M" first="Michaël" last="Angio">Michaël Angio</name></author><author><name sortKey="Grentzinger, Alain" sort="Grentzinger, Alain" uniqKey="Grentzinger A" first="Alain" last="Grentzinger">Alain Grentzinger</name></author><author><name sortKey="Virion, Jean M" sort="Virion, Jean M" uniqKey="Virion J" first="Jean M" last="Virion">Jean M. Virion</name></author><author><name sortKey="Brouant, Benoit" sort="Brouant, Benoit" uniqKey="Brouant B" first="Benoit" last="Brouant">Benoit Brouant</name></author><author><name sortKey="Olivier, Pierre" sort="Olivier, Pierre" uniqKey="Olivier P" first="Pierre" last="Olivier">Pierre Olivier</name></author><author><name sortKey="Karcher, Gilles" sort="Karcher, Gilles" uniqKey="Karcher G" first="Gilles" last="Karcher">Gilles Karcher</name></author><author><name sortKey="Juilliere, Yves" sort="Juilliere, Yves" uniqKey="Juilliere Y" first="Yves" last="Juillière">Yves Juillière</name></author><author><name sortKey="Zannad, Fa Ez" sort="Zannad, Fa Ez" uniqKey="Zannad F" first="Fa Ez" last="Zannad">Fa Ez Zannad</name></author><author><name sortKey="Bertrand, Alain" sort="Bertrand, Alain" uniqKey="Bertrand A" first="Alain" last="Bertrand">Alain Bertrand</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2F5441473DAB4960D8C52AA2265C51AC0BC20750</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0735-1097(99)00156-4</idno><idno type="url">https://api.istex.fr/document/2F5441473DAB4960D8C52AA2265C51AC0BC20750/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000782</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="ISTEX">000782</idno><idno type="wicri:Area/Main/Curation">000782</idno><idno type="wicri:Area/Main/Exploration">000A07</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">000A07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging</title><author><name sortKey="Marie, Pierre Y" sort="Marie, Pierre Y" uniqKey="Marie P" first="Pierre Y" last="Marie">Pierre Y. Marie</name><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Nuclear Medicine, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Danchin, Nicolas" sort="Danchin, Nicolas" uniqKey="Danchin N" first="Nicolas" last="Danchin">Nicolas Danchin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Branly, Fabrice" sort="Branly, Fabrice" uniqKey="Branly F" first="Fabrice" last="Branly">Fabrice Branly</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Nuclear Medicine, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Angio, Michael" sort="Angio, Michael" uniqKey="Angio M" first="Michaël" last="Angio">Michaël Angio</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Grentzinger, Alain" sort="Grentzinger, Alain" uniqKey="Grentzinger A" first="Alain" last="Grentzinger">Alain Grentzinger</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Virion, Jean M" sort="Virion, Jean M" uniqKey="Virion J" first="Jean M" last="Virion">Jean M. Virion</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Medicine Computer Science, Epidemiology and Statistics, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Brouant, Benoit" sort="Brouant, Benoit" uniqKey="Brouant B" first="Benoit" last="Brouant">Benoit Brouant</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Olivier, Pierre" sort="Olivier, Pierre" uniqKey="Olivier P" first="Pierre" last="Olivier">Pierre Olivier</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Nuclear Medicine, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Karcher, Gilles" sort="Karcher, Gilles" uniqKey="Karcher G" first="Gilles" last="Karcher">Gilles Karcher</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Nuclear Medicine, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Juilliere, Yves" sort="Juilliere, Yves" uniqKey="Juilliere Y" first="Yves" last="Juillière">Yves Juillière</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Zannad, Fa Ez" sort="Zannad, Fa Ez" uniqKey="Zannad F" first="Fa Ez" last="Zannad">Fa Ez Zannad</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Bertrand, Alain" sort="Bertrand, Alain" uniqKey="Bertrand A" first="Alain" last="Bertrand">Alain Bertrand</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Nuclear Medicine, UPRES EA 2403, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American College of Cardiology</title><title level="j" type="abbrev">JAC</title><idno type="ISSN">0735-1097</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="vol">34</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="113">113</biblScope><biblScope unit="page" to="121">121</biblScope></imprint><idno type="ISSN">0735-1097</idno></series><idno type="istex">2F5441473DAB4960D8C52AA2265C51AC0BC20750</idno><idno type="DOI">10.1016/S0735-1097(99)00156-4</idno><idno type="PII">S0735-1097(99)00156-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0735-1097</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CHD</term><term>CI</term><term>LAD</term><term>RR</term><term>SPECT</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVES The purpose of this study was to determine whether antianginal medications modify the prognostic significance of exercise single photon emission computed tomography (SPECT) ischemia. BACKGROUND Antianginal medications (especially beta-adrenergic blocking agents) limit exercise SPECT ischemia, but it is not known whether such medications also modify the prognostic effect of exercise SPECT ischemia. METHODS We included 352 patients with coronary heart disease, who had exercise Tl-201 SPECT and coronary angiography, and who were initially treated medically. Survival Cox models were applied in patients for whom classes of antianginal medications taken at exercise SPECT were the same as those prescribed for follow-up (GI; n = 136), and in patients for whom new classes of antianginal medications, including beta-blockers (GII; n = 79) or not including beta-blockers (GIII; n = 113), were added for follow-up. RESULTS During a mean 5.3 ± 1.6 years of follow-up, 45 patients had cardiac death or myocardial infarction. Variables reflecting necrosis (irreversible defect extent, left ventricular ejection fraction) and those from coronary angiography provided equivalent prognostic information in the three groups. In contrast, the SPECT variable reflecting ischemia (reversible defect extent), which provided comparable prognostic information in GI (p = 0.005) and GIII (p = 0.004), lost its prognostic significance (p = 0.54) in GII, and was associated with a lower relative risk in GII than in GI or GIII (both p < 0.05). CONCLUSIONS In patients with coronary heart disease, the introduction of antianginal medications, when including beta-blockers, appears to have a favorable effect on the deleterious prognostic effect of exercise ischemia. </div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Marie, Pierre Y" sort="Marie, Pierre Y" uniqKey="Marie P" first="Pierre Y" last="Marie">Pierre Y. Marie</name></noRegion><name sortKey="Angio, Michael" sort="Angio, Michael" uniqKey="Angio M" first="Michaël" last="Angio">Michaël Angio</name><name sortKey="Bertrand, Alain" sort="Bertrand, Alain" uniqKey="Bertrand A" first="Alain" last="Bertrand">Alain Bertrand</name><name sortKey="Branly, Fabrice" sort="Branly, Fabrice" uniqKey="Branly F" first="Fabrice" last="Branly">Fabrice Branly</name><name sortKey="Brouant, Benoit" sort="Brouant, Benoit" uniqKey="Brouant B" first="Benoit" last="Brouant">Benoit Brouant</name><name sortKey="Danchin, Nicolas" sort="Danchin, Nicolas" uniqKey="Danchin N" first="Nicolas" last="Danchin">Nicolas Danchin</name><name sortKey="Grentzinger, Alain" sort="Grentzinger, Alain" uniqKey="Grentzinger A" first="Alain" last="Grentzinger">Alain Grentzinger</name><name sortKey="Juilliere, Yves" sort="Juilliere, Yves" uniqKey="Juilliere Y" first="Yves" last="Juillière">Yves Juillière</name><name sortKey="Karcher, Gilles" sort="Karcher, Gilles" uniqKey="Karcher G" first="Gilles" last="Karcher">Gilles Karcher</name><name sortKey="Marie, Pierre Y" sort="Marie, Pierre Y" uniqKey="Marie P" first="Pierre Y" last="Marie">Pierre Y. Marie</name><name sortKey="Olivier, Pierre" sort="Olivier, Pierre" uniqKey="Olivier P" first="Pierre" last="Olivier">Pierre Olivier</name><name sortKey="Virion, Jean M" sort="Virion, Jean M" uniqKey="Virion J" first="Jean M" last="Virion">Jean M. Virion</name><name sortKey="Zannad, Fa Ez" sort="Zannad, Fa Ez" uniqKey="Zannad F" first="Fa Ez" last="Zannad">Fa Ez Zannad</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Wicri/explor/CircusV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A07 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A07 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Wicri
|area= CircusV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:2F5441473DAB4960D8C52AA2265C51AC0BC20750
|texte= Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging
}}
| This area was generated with Dilib version V0.6.31. |  |